Glycans are involved in numerous biological recognition events. Being secondary gene
products, their labeling by genetic methods–comparable to GFP labeling of proteins–is not …

The vast array of cell types of multicellular organisms must individually fine-tune their
internal metabolism. One important metabolic and stress regulatory mechanism is the …

Conspectus Although lipids are not genetically encoded, they are fundamental building
blocks of cell membranes and essential components of cell metabolites. Lipids regulate …

O-Linked β-N-acetylglucosamine (O-GlcNAc) is an essential, dynamic monosaccharide post-
translational modification (PTM) found on serine and threonine residues of thousands of …

Exo-enzymatic glyco-engineering of cell-surface glycoconjugates enables the selective
display of well-defined glyco-motifs bearing bioorthogonal functional groups, which can be …

Sugar additions to biomolecules, or glycans, are some of the most abundant biomolecule
modifications in biology because they enable cells to adapt to changing nutrient and stress …

Protein O− GlcNAcylation is a ubiquitous posttranslational modification of cytosolic and
nuclear proteins involved in numerous fundamental regulation processes. Investigation of …

Tumor cells are decorated with aberrant glycan structures on cell surfaces. It is well known
that the glycocalyx serves as a main cellular regulator, although its role in cancer is still not …

In classic bioorthogonal labeling experiments, the cell's biosynthetic machinery incorporates
bioorthogonal tags, creating tagged biomolecules that are subsequently reacted with a …

O-GlcNAcylation is a ubiquitous post-translational modification governing vital biological
processes in cancer, diabetes and neurodegeneration. Metabolic chemical reporters …