CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …

Drug resistance represents the major reason of pharmacological treatment failure. It is
supported by a broad spectrum of mechanisms, whose molecular bases have been …

Heat shock protein 27 (HSP27), induced by heat shock, environmental, and
pathophysiological stressors, is a multi-functional protein that acts as a protein chaperone …

Background Protein kinase CK2 inhibition has long been considered as an attractive anti-
cancer strategy based on the following considerations: CK2 is a pro-survival kinase, it is …

The ubiquitin‐proteasome system is a crucial mechanism for regulating protein levels in
cells, with substrate‐specific E3 ubiquitin ligases serving as an integral component of this …

Simple Summary Heat shock proteins (HSPs) are extensively distributed throughout cells.
They play a crucial role as molecular chaperones and regulate various cellular processes …

Background Similarities in the hijacking mechanisms used by SARS-CoV-2 and several
types of cancer, suggest the repurposing of cancer drugs to treat Covid-19. CK2 kinase …

In gliomas, casein kinase 2 (CK2) plays a dominant role in cell survival and tumour
invasiveness and is upregulated in many brain tumours. Among CK2 inhibitors …

Simple Summary Among the many mechanisms developed by cancer cells in order to
survive and sustain constant proliferation under stress conditions, a system based on heat …

F508del-CFTR, the most common mutation in cystic fibrosis (CF) patients, impairs CFTR
trafficking to plasma membrane leading to its premature proteasomal degradation. Several …