Apoptosis in Alzheimer's disease: insight into the signaling pathways and therapeutic avenues

S Kumari, R Dhapola, DHK Reddy - Apoptosis, 2023 - Springer
Alzheimer's disease (AD) is characterized by the accumulation of hyperphosphorylated tau
and amyloid-β (Aβ) protein resulting in synaptic loss and apoptosis. Aβ and tau deposition …

Imaging the substantia nigra in Parkinson disease and other Parkinsonian syndromes

YJ Bae, JM Kim, CH Sohn, JH Choi, BS Choi, YS Song… - Radiology, 2021 - pubs.rsna.org
Parkinson disease is characterized by dopaminergic cell loss in the substantia nigra of the
midbrain. There are various imaging markers for Parkinson disease. Recent advances in …

The detection of Parkinson disease using the genetic algorithm and SVM classifier

Z Soumaya, BD Taoufiq, N Benayad, K Yunus… - Applied Acoustics, 2021 - Elsevier
The speech signal is like the black box of human beings where much information is hidden.
The treatment of this signal provides us with the speaker's identity. In a way, it is similar to an …

[HTML][HTML] Why senescent cells are resistant to apoptosis: an insight for senolytic development

L Hu, H Li, M Zi, W Li, J Liu, Y Yang, D Zhou… - Frontiers in Cell and …, 2022 - frontiersin.org
Cellular senescence is a process that leads to a state of irreversible cell growth arrest
induced by a variety of intrinsic and extrinsic stresses. Senescent cells (SnCs) accumulate …

Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies

JA Palma, H Kaufmann - Movement Disorders, 2018 - Wiley Online Library
Dysfunction of the autonomic nervous system afflicts most patients with Parkinson disease
and other synucleinopathies such as dementia with Lewy bodies, multiple system atrophy …

Synaptic changes in Parkinson disease assessed with in vivo imaging

D Matuskey, S Tinaz, KC Wilcox… - Annals of …, 2020 - Wiley Online Library
Objective Parkinson disease is characterized by motor and nonmotor symptoms, reduced
striatal dopamine signaling, and loss of dopamine neurons in the substantia nigra. It is now …

[HTML][HTML] Programmed cell death in diabetic nephropathy: a review of apoptosis, autophagy, and necroptosis

NS Erekat - Medical Science Monitor: International Medical Journal …, 2022 - ncbi.nlm.nih.gov
Diabetic nephropathy is a common complication of type I and type II diabetes, in which renal
glomeruli are destroyed, resulting in renal damage, proteinuria, and hypertension …

SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models

OC Kwon, JJ Song, Y Yang, SH Kim, JY Kim… - EMBO Molecular …, 2021 - embopress.org
Astrocytes and microglia are brain‐resident glia that can establish harmful inflammatory
environments in disease contexts and thereby contribute to the progression of neuronal loss …

Dihydroxy-metabolites of dihomo-γ-linolenic acid drive ferroptosis-mediated neurodegeneration

M Sarparast, E Pourmand, J Hinman… - ACS Central …, 2023 - ACS Publications
Even after decades of research, the mechanism of neurodegeneration remains
understudied, hindering the discovery of effective treatments for neurodegenerative …

[HTML][HTML] Role of induced programmed cell death in the chemopreventive potential of apigenin

JY Jang, B Sung, ND Kim - International Journal of Molecular Sciences, 2022 - mdpi.com
The flavonoid apigenin (4′, 5, 7-trihydroxyflavone), which is one of the most widely
distributed phytochemicals in the plant kingdom, is one of the most thoroughly investigated …