SARS-CoV-2 Omicron variants: burden of disease, impact on vaccine effectiveness and need for variant-adapted vaccines

S Pather, SA Madhi, BJ Cowling, P Moss… - Frontiers in …, 2023 - frontiersin.org
The highly transmissible Omicron (B. 1.1. 529) variant of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) was first detected in late 2021. Initial Omicron waves were …

Hybrid immunity to SARS-CoV-2 from infection and vaccination—evidence synthesis and implications for new COVID-19 vaccines

JR Spinardi, A Srivastava - Biomedicines, 2023 - mdpi.com
COVID-19 has taken a severe toll on the global population through infections,
hospitalizations, and deaths. Elucidating SARS-CoV-2 infection-derived immunity has led to …

Low neutralization of SARS-CoV-2 Omicron BA. 2.75. 2, BQ. 1.1 and XBB. 1 by parental mRNA vaccine or a BA. 5 bivalent booster

C Kurhade, J Zou, H Xia, M Liu, HC Chang, P Ren… - Nature medicine, 2023 - nature.com
The newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Omicron sublineages, including the BA. 2-derived BA. 2.75. 2 and the BA. 5-derived BQ. 1.1 …

Neutralization of ba. 4–ba. 5, ba. 4.6, ba. 2.75. 2, bq. 1.1, and xbb. 1 with bivalent vaccine

J Zou, C Kurhade, S Patel, N Kitchin… - … England Journal of …, 2023 - Mass Medical Soc
Neutralization of BA.4–BA.5, BA.4.6, BA.2.75.2, BQ.1.1, and XBB.1 with Bivalent Vaccine | New
England Journal of Medicine Skip to main content The New England Journal of Medicine …

Bivalent omicron BA. 1–adapted BNT162b2 booster in adults older than 55 years

P Winokur, J Gayed, D Fitz-Patrick… - … England Journal of …, 2023 - Mass Medical Soc
Background The emergence of immune-escape variants of severe acute respiratory
syndrome coronavirus 2 warrants the use of sequence-adapted vaccines to provide …

[HTML][HTML] Characterization of SARS-CoV-2 recombinants and emerging Omicron sublineages

Y Wang, Y Long, F Wang, C Li, W Liu - International journal of …, 2023 - ncbi.nlm.nih.gov
Abstract The SARS-CoV-2 Omicron is currently the predominant circulating variant in the
COVID-19 pandemic. The dominating Omicron sublineages respond to host immune …

An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif

Y Fang, P Sun, X Xie, M Du, F Du, J Ye… - Science …, 2022 - science.org
The rapid evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
such as the Omicron variants that are highly transmissible and immune evasive …

Reverse genetic systems of SARS-CoV-2 for antiviral research

C Kurhade, X Xie, PY Shi - Antiviral research, 2023 - Elsevier
Reverse genetic systems are widely used to engineer recombinant viruses with desired
mutations. In response to the COVID-19 pandemic, four types of reverse genetic systems …

Cross-neutralization and viral fitness of SARS-CoV-2 Omicron sublineages

H Xia, J Yeung, B Kalveram, CJ Bills… - Emerging microbes & …, 2023 - Taylor & Francis
The rapid evolution of SARS-CoV-2 Omicron sublineages mandates a better understanding
of viral replication and cross-neutralization among these sublineages. Here we used K18 …

Clinical development of variant-adapted BNT162b2 COVID-19 vaccines: The early Omicron era

S Pather, A Muik, R Rizzi, F Mensa - Expert Review of Vaccines, 2023 - Taylor & Francis
ABSTRACT Introduction The Omicron BA. 1 variant of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) and subsequent sub-lineages exhibit partial escape from …