The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …

In arbitrary dimension, in the discrete setting of finite-differences we prove a Carleman
estimate for a semi-discrete parabolic operator, in which the large parameter is connected to …

Transporters influence the disposition of chemicals within the body by participating in
absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) …

Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …

The sites of plant flavonoid biosynthesis, storage and final function often differ at the
subcellular, cell, and even tissue and organ levels. Efficient transport systems for flavonoids …

Multidrug efflux pumps have emerged as relevant elements in the intrinsic and acquired
antibiotic resistance of bacterial pathogens. In contrast with other antibiotic resistance genes …

Crop yields are significantly reduced by aluminum (Al) toxicity on acidic soils, which
comprise up to 50% of the world's arable land. Al‐activated release of ligands (such as …

Platinum-based drugs are among the most active anticancer agents and are successfully
used in a wide variety of human malignancies. However, acquired and/or intrinsic resistance …

A microdose study of metformin was conducted to investigate the predictability of drug–drug
interactions at the therapeutic dose (ThD). Healthy subjects received a microdose (100 µg) …

Metformin is the most widely prescribed oral antiglycemic drug, with few adverse effects.
However, surprisingly little is known about its human biodistribution and target tissue …