In the brain, most synapses are formed on minute protrusions known as dendritic spines.
Unlike their artificial intelligence counterparts, spines are not merely tuneable memory …

The neural circuits responsible for animal behavior remain largely unknown. We summarize
new methods and present the circuitry of a large fraction of the brain of the fruit fly …

Neurons in the developing brain undergo extensive structural refinement as nascent circuits
adopt their mature form. This physical transformation of neurons is facilitated by the …

We assembled a semi-automated reconstruction of L2/3 mouse primary visual cortex from∼
250× 140× 90 μm 3 of electron microscopic images, including pyramidal and non-pyramidal …

Due to advances in automated image acquisition and analysis, whole-brain connectomes
with 100,000 or more neurons are on the horizon. Proofreading of whole-brain automated …

To understand the brain we must relate neurons' functional responses to the circuit
architecture that shapes them. Here, we present a large functional connectomics dataset …

Connections between neurons can be mapped by acquiring and analyzing electron
microscopic (EM) brain images. In recent years, this approach has been applied to chunks of …

Inhibitory neurons in mammalian cortex exhibit diverse physiological, morphological,
molecular, and connectivity signatures. While considerable work has measured the average …

Conventional theories assume that long-term information storage in the brain is
implemented by modifying synaptic efficacy. Recent experimental findings challenge this …

Advances in brain connectomics have demonstrated the extraordinary complexity of neural
circuits. 1, 2, 3, 4, 5 Developing neurons encounter the axons and dendrites of many …