Discovery, structure and biological activities of cyclotides
Cyclotides are small disulfide-rich peptides that are characterized by a head-to-tail cyclized
peptide backbone and a knotted arrangement of three conserved disulfide bonds. They are …
peptide backbone and a knotted arrangement of three conserved disulfide bonds. They are …
In vitro methods for peptide display and their applications
CG Ullman, L Frigotto, RN Cooley - Briefings in functional …, 2011 - academic.oup.com
The presentation of recombinant peptide libraries linked to their coding sequence can be
referred to as 'peptide display'. Phage display is the most widely practiced peptide display …
referred to as 'peptide display'. Phage display is the most widely practiced peptide display …
[HTML][HTML] HER2-positive breast cancer targeting and treatment by a peptide-conjugated mini nanodrug
H Ding, PR Gangalum, A Galstyan, I Fox, R Patil… - … , Biology and Medicine, 2017 - Elsevier
HER2+ breast cancer is one of the most aggressive forms of breast cancer. The new
polymalic acid-based mini nanodrug copolymers are synthesized and specifically …
polymalic acid-based mini nanodrug copolymers are synthesized and specifically …
Phage display libraries of differently sized bicyclic peptides
Phage selections with combinatorial libraries of uniformly sized bicyclic peptides have
recently yielded potent and selective binders of several protein targets. In this work we …
recently yielded potent and selective binders of several protein targets. In this work we …
Structure and modeling of knottins, a promising molecular scaffold for drug discovery
J Gracy, L Chiche - Current pharmaceutical design, 2011 - ingentaconnect.com
The knottins are extremely stable miniproteins present in many species and are able to
perform various tasks. Owing to its small size and its amazing stability, the knottin structural …
perform various tasks. Owing to its small size and its amazing stability, the knottin structural …
Display Technologies for Expanding the Pharmaceutical Applications of Cyclotides
J Xie, MW Kan, SJ de Veer, C Wang… - Israel Journal of …, 2024 - Wiley Online Library
Cyclotides are ultra‐stable peptides originally discovered in plants based on their medicinal
applications. Their natural function is as host defence agents. They are amenable to …
applications. Their natural function is as host defence agents. They are amenable to …
Phage display selection of miniprotein binders of the Estrogen Receptor
Miniprotein phage display screening yields structured peptides with high affinity for the
Estrogen Receptor (ER). Hits from apamin phage libraries feature a LXXLL motif specifically …
Estrogen Receptor (ER). Hits from apamin phage libraries feature a LXXLL motif specifically …
Supramolecular surface immobilization of knottin derivatives for dynamic display of high affinity binders
Knottins are known as a robust and versatile class of miniprotein scaffolds for the
presentation of high-affinity binding peptides; however, to date their application in …
presentation of high-affinity binding peptides; however, to date their application in …
Engineering anti-vascular endothelial growth factor single chain disulfide-stabilized antibody variable fragments (sc-dsFv) with phage-displayed sc-dsFv libraries
Phage display of antibody fragments from natural or synthetic antibody libraries with the
single chain constructs combining the variable fragments (scFv) has been one of the most …
single chain constructs combining the variable fragments (scFv) has been one of the most …
A disulfide-constrained miniprotein with striking tumor-binding specificity developed by ribosome display.
F Zoller, A Markert, P Barthe… - Angewandte …, 2013 - search.ebscohost.com
Fold me to hold me: A specific binding agent against the delta‐like ligand 4 protein, which is
expressed in angiogenesis, was identified by ribosome display. Specific tumor binding of …
expressed in angiogenesis, was identified by ribosome display. Specific tumor binding of …