Parkinson's disease (PD) is a progressive neurodegenerative disease where dopaminergic
neurons in the substantia nigra are lost, resulting in a decrease in striatal dopamine and …

Parkinson's disease is an increasingly prevalent and currently incurable neurodegenerative
disorder. At the molecular level, this disease is characterized by the formation of aberrant …

Abstract α-Synuclein (αS) is a presynaptic disordered protein whose aberrant aggregation is
associated with Parkinson's disease. The functional role of αS is still debated, although it …

Since the initial identification of alpha-synuclein (α-syn) at the synapse, numerous studies
demonstrated that α-syn is a key player in the etiology of Parkinson's disease (PD) and other …

Parkinson's disease (PD) is a neurodegenerative disease characterized by deposition of α-
synuclein and aggregation of Lewy bodies. Cholesterol is involved with PD neuropathology …

Parkinson's disease is characterised by the presence in brain tissue of aberrant inclusions
known as Lewy bodies and Lewy neurites, which are deposits composed by α-synuclein …

Alpha-synuclein (αSyn) is a highly expressed and conserved protein, typically found in the
presynaptic terminals of neurons. The misfolding and aggregation of αSyn into amyloid …

Genetic alterations in the LRRK2 gene, encoding leucine-rich repeat kinase 2, are a
common risk factor for Parkinson's disease. How LRRK2 alterations lead to cell pathology is …

Statins are common drugs that are clinically used to reduce elevated plasma cholesterol
levels. Based on their solubility, statins are considered to be either hydrophilic or lipophilic …

Nature confines hundreds of millimolar of amphiphilic neurotransmitters, such as serotonin,
in synaptic vesicles. This appears to be a puzzle, as the mechanical properties of lipid …