Clinical trials in amyotrophic lateral sclerosis: why so many negative trials and how can trials be improved?

H Mitsumoto, BR Brooks, V Silani - The Lancet Neurology, 2014 - thelancet.com
Amyotrophic lateral sclerosis (ALS) is one of the most rapidly progressive
neurodegenerative diseases of unknown cause. Riluzole is the only drug that slows disease …

Symptomatic treatments for amyotrophic lateral sclerosis/motor neuron disease

L Ng, F Khan, CA Young… - Cochrane Database of …, 2017 - cochranelibrary.com
Symptomatic treatments for amyotrophic lateral sclerosis/motor neuron disease - Ng, L - 2017 |
Cochrane Library Skip to Content Cookies Our site uses cookies to improve your experience …

Impact of expiratory strength training in amyotrophic lateral sclerosis: Results of a randomized, sham‐controlled trial

EK Plowman, L Tabor‐Gray, KM Rosado… - Muscle & …, 2019 - Wiley Online Library
Introduction The purpose of this study was to determine the impact of an in‐home expiratory
muscle strength training (EMST) program on pulmonary, swallow, and cough function in …

Physical activity and lifestyle modifications in the treatment of neurodegenerative diseases

JA Santiago, JA Potashkin - Frontiers in Aging Neuroscience, 2023 - frontiersin.org
Neurodegenerative diseases have reached alarming numbers in the past decade.
Unfortunately, clinical trials testing potential therapeutics have proven futile. In the absence …

Therapeutic exercise for people with amyotrophic lateral sclerosis or motor neuron disease

V Dal Bello‐Haas, JM Florence - Cochrane Database of …, 2013 - cochranelibrary.com
Background Despite the high incidence of muscle weakness in individuals with amyotrophic
lateral sclerosis (ALS) or motor neuron disease (MND), the effects of exercise in this …

Disease-modifying and symptomatic treatment of amyotrophic lateral sclerosis

J Dorst, AC Ludolph, A Huebers - Therapeutic advances in …, 2018 - journals.sagepub.com
In this review, we summarize the most important recent developments in the treatment of
amyotrophic lateral sclerosis (ALS). In terms of disease-modifying treatment options, several …

Rehabilitation in amyotrophic lateral sclerosis: why it matters

S Majmudar, J Wu, S Paganoni - Muscle & nerve, 2014 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that results in a
constellation of problematic symptoms and a high patient and caregiver burden …

Canadian best practice recommendations for the management of amyotrophic lateral sclerosis

C Shoesmith, A Abrahao, T Benstead, M Chum… - Cmaj, 2020 - Can Med Assoc
The care and management of patients with ALS should always be patient focused, with
attention to holistic and emotional aspects of well-being. It is the patient who ultimately …

Mitophagy and the brain

NS Swerdlow, HM Wilkins - International journal of molecular sciences, 2020 - mdpi.com
Stress mechanisms have long been associated with neuronal loss and neurodegenerative
diseases. The origin of cell stress and neuronal loss likely stems from multiple pathways …

Mechanisms of exercise as a preventative measure to muscle wasting

ZA Graham, KM Lavin, SM O'Bryan… - … of Physiology-Cell …, 2021 - journals.physiology.org
Skeletal muscle is the most abundant tissue in healthy individuals and it has important roles
in health beyond voluntary movement. The overall mass and energy requirements of …