This review presents lower body negative pressure (LBNP) as a unique tool to investigate
the physiology of integrated systemic compensatory responses to altered hemodynamic …

The direct (eg, radiation, microgravity) and indirect (eg, lifestyle perturbations) effects of
spaceflight extend across multiple systems resulting in whole-organism cardiovascular …

Hypertension is a risk factor for cardiovascular morbidity and mortality with increasing
prevalence with age, whose treatment is associated with benefits over fatal and non-fatal …

During head-down tilt bed rest (HDT) the cardiovascular system is subject to headward fluid
shifts. The fluid shift phenomenon is analogous to weightlessness experienced during …

Simple Summary Lymphedema is a chronic, debilitating disease of the lymphatic
vasculature. Although several reviews focus on the anatomy and physiology of the lymphatic …

To understand fundamental mechanisms associated with post-flight orthostatic intolerance
we investigated the interaction between the cardiovascular and postural functions before …

Space flight-induced physiological deconditioning resulting from decreased gravitational
input, decreased plasma volume, and disruption of regulatory mechanisms is a significant …

As part of the first Canadian aging and inactivity study (CAIS) we assessed the efficacy of
space-based exercise countermeasures for maintenance of cardiac and muscle-pump …

Older individuals experience cardiovascular dysfunction during extended bedridden
hospital or care home stays. Bed rest is also used as a model to simulate accelerated …

Multisensory integration is essential for maintenance of motor and cognitive abilities, thereby
ensuring normal function and personal autonomy. Balance control is challenged during …