A current challenge in cancer treatment is drug resistance. Even the most effective therapies
often fail to produce a complete and durable tumor response and ultimately give rise to …

Much has been made about JLW Thudichum's colorful, and one could say clairvoyant,
naming of sphingosine “in commemoration of the many enigmas which it presented to the …

Purpose: The goals of the study were to elucidate the immune mechanisms that contribute to
desirable complete remissions of murine colon tumors treated with single radiation dose of …

Targeted alpha therapy (TAT) using alpha particle-emitting radionuclides is in the spotlight
after the approval of 223RaCl2 for patients with metastatic castration-resistant prostate …

Growing evidence supports the concept that Alzheimer's disease (AD) is fundamentally a
metabolic disease with molecular and biochemical features that correspond with diabetes …

The crucial role of lipids in cell, tissue and organ physiology is demonstrated by a large
number of genetic studies and by many human diseases that involve the disruption of lipid …

Obesity predisposes individuals to the development of insulin resistance in skeletal muscle
and the liver, and researchers have recently proposed two mechanisms by which excess …

Lipidomics has been proving that membrane lipids play a crucial role in several cell
functions and are involved in several pathologies, including cancer. In fact, beyond a …

The past few years have provided substantial evidence for the vital role of the local tumor
microenvironment for various aspects of tumor progression. With obesity and its …

All cancers tested so far display abnormal choline and ethanolamine phospholipid
metabolism, which has been detected with numerous magnetic resonance spectroscopy …