The total and regional peripheral resistance and capacitance of the vascular system is
regulated by the sympathetic nervous system, which influences the vasculature mainly …

α2-Adrenergic receptors mediate part of the diverse biological effects of the endogenous
catecholamines epinephrine and norepinephrine. Three distinct subtypes of α2-adrenergic …

Dexmedetomidine offers beneficial pharmacological properties, providing dose-dependent
sedation, analgesia, sympatholysis and anxiolysis without relevant respiratory depression …

Different studies have led to our present knowledge of the membrane receptors responsible
for mediating the responses to the endogenous catecholamines. These receptors were …

Background: Exposure to particulate matter≤ 2.5 μm in diameter (PM2. 5) increases blood
pressure (BP) in humans and animal models. Abnormal activation of the sympathetic …

Adenosine has been described as playing a role in the control of inflammation, but it has not
been certain which of its receptors mediate this effect. Here, we generated an A2B …

Mice with altered α2-adrenergic receptor genes have become important tools in elucidating
the subtype-specific functions of the three α2-adrenergic receptor subtypes because of the …

α2-Adrenoceptors are involved in various physiological functions, particularly in the
cardiovascular system and the central nervous system. Different adrenoceptor subtypes …

The α2A-adrenergic receptor (AR) subtype mediates antinociception induced by the α2AR
agonists clonidine, dexmedetomidine, norepinephrine, and 5-bromo-N-(4, 5-dihydro-1 H …

A polymorphic variant of the human α 2B-adrenergic receptor (α 2B AR), which consists of a
deletion of three glutamic acids (residues 301–303) in the third intracellular loop was found …