Bone morphogenic proteins (BMPs) are important growth regulators in embryogenesis and
postnatal homeostasis. Their tight regulation is crucial for successful embryonic …

In this article, I put forward the idea that the neoplastic process (NP) has deep evolutionary
roots and makes specific predictions about the connection between cancer and the …

BMP‐1/tolloid‐like proteinases belong to the astacin family of human metalloproteinases,
together with meprins and ovastacin. They represent promising targets to treat or prevent a …

The development of cardiovascular disease is intimately linked to elevated levels of low-
density lipoprotein (LDL) cholesterol in the blood. Hepatic LDL receptor (LDLR) levels …

Growth differentiation factor 8 (GDF8), aka myostatin, is a member of the larger TGFβ
superfamily of signaling ligands. GDF8 has been well characterized as a negative regulator …

Bone morphogenetic protein 1 (BMP1), a member of the astacin family of zinc‐
metalloproteases, proteolytically cleaves the low‐density lipoprotein receptor (LDLR) within …

Tolloid proteinases are essential for tissue patterning and extracellular matrix assembly. The
members of the family differ in their substrate specificity and activity, despite sharing similar …

Left ventricular noncompaction (LVNC) is an inherited cardiomyopathy involving numerous
genes. To identify novel candidate causal mutations, a whole exome sequencing study was …

Abstract Growth differentiation factor 8 (GDF8), aka myostatin, is a member of the activin
subclass within the larger TGFß superfamily of signaling ligands that contains over 30 …