The anthracycline drug doxorubicin is among the most used—and useful—
chemotherapeutics. While doxorubicin is highly effective in the treatment of various …

Background Anti-cancer therapy is often a cause of premature ovarian insufficiency and
infertility since the ovarian follicle reserve is extremely sensitive to the effects of …

Objective To report ovarian tissue autotransplantation (AT) results and describe the
relationship between technical and clinical factors and outcomes. Design Multicenter …

BACKGROUND Chemotherapy treatment in premenopausal women is associated with an
increased risk of premature ovarian failure (POF) but the exact mechanism through which …

In the last years, thanks to the improvement in the prognosis of cancer patients, a growing
attention has been given to the fertility issues. International guidelines on fertility …

Purpose Chemotherapy treatment in premenopausal women has been linked to ovarian
follicle loss and premature ovarian failure; the exact mechanism by which this occurs is …

Recent advances in our understanding of the mechanisms underlying the impact of cytotoxic
drugs on the ovary have opened up new directions for the protection of the ovary from …

BACKGROUND Current options for female fertility preservation in the face of cytotoxic
treatments include embryo, oocyte and ovarian tissue cryopreservation. However these …

Throughout the female menstrual cycle, physiological changes occur that affect the
biodistribution of nanoparticles within the reproductive system. We demonstrate a 2-fold …

The anticancer drug doxorubicin has been associated with several adverse side-effects
including reproductive toxicity in both genders. The current review has complied the …