The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer
JL Hsu, MC Hung - Cancer and Metastasis Reviews, 2016 - Springer
Breast cancer affects approximately 1 in 8 women, and it is estimated that over 246,660
women in the USA will be diagnosed with breast cancer in 2016. Breast cancer mortality has …
women in the USA will be diagnosed with breast cancer in 2016. Breast cancer mortality has …
Molecular targeting therapy against EGFR family in breast cancer: progress and future potentials
AE Maennling, MK Tur, M Niebert, T Klockenbring… - Cancers, 2019 - mdpi.com
The epidermal growth factor receptor (EGFR) family contains four transmembrane tyrosine
kinases (EGFR1/ErbB1, Her2/ErbB2, Her3/ErbB3 and Her4/ErbB4) and 13 secreted …
kinases (EGFR1/ErbB1, Her2/ErbB2, Her3/ErbB3 and Her4/ErbB4) and 13 secreted …
Targeting the EGFR signaling pathway in cancer therapy
P Seshacharyulu, MP Ponnusamy… - Expert opinion on …, 2012 - Taylor & Francis
Introduction: Cancer is a devastating disease; however, several therapeutic advances have
recently been made, wherein EGFR and its family members have emerged as useful …
recently been made, wherein EGFR and its family members have emerged as useful …
Mechanisms of phytonutrient modulation of cyclooxygenase-2 (COX-2) and inflammation related to cancer
SJ Desai, B Prickril, A Rasooly - Nutrition and cancer, 2018 - Taylor & Francis
The link between chronic inflammation and cancer involves cytokines and mediators of
inflammatory pathways. Cyclooxygenase-2 (COX-2), a key enzyme in fatty acid metabolism …
inflammatory pathways. Cyclooxygenase-2 (COX-2), a key enzyme in fatty acid metabolism …
EGF–ERBB signalling: towards the systems level
A Citri, Y Yarden - Nature reviews Molecular cell biology, 2006 - nature.com
Signalling through the ERBB/HER receptors is intricately involved in human cancer and
already serves as a target for several cancer drugs. Because of its inherent complexity, it is …
already serves as a target for several cancer drugs. Because of its inherent complexity, it is …
The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis
MM Moasser - Oncogene, 2007 - nature.com
The year 2007 marks exactly two decades since Human Epidermal Growth Factor Receptor-
2 (HER2) was functionally implicated in the pathogenesis of human breast cancer. This …
2 (HER2) was functionally implicated in the pathogenesis of human breast cancer. This …
The role of HER2 in cancer therapy and targeted drug delivery
HER2 is highly expressed in a significant proportion of breast cancer, ovarian cancer, and
gastric cancer. Since the discovery of its role in tumorigenesis, HER2 has received great …
gastric cancer. Since the discovery of its role in tumorigenesis, HER2 has received great …
The epidermal growth factor receptor family: biology driving targeted therapeutics
MJ Wieduwilt, MM Moasser - Cellular and molecular life sciences, 2008 - Springer
The epidermal growth factor family of receptor tyrosine kinases (ErbBs) plays essential roles
in regulating cell proliferation, survival, differentiation and migration. The ErbB receptors …
in regulating cell proliferation, survival, differentiation and migration. The ErbB receptors …
Protein localization in disease and therapy
The eukaryotic cell is organized into membrane-covered compartments that are
characterized by specific sets of proteins and biochemically distinct cellular processes. The …
characterized by specific sets of proteins and biochemically distinct cellular processes. The …
Derailed endocytosis: an emerging feature of cancer
Y Mosesson, GB Mills, Y Yarden - Nature Reviews Cancer, 2008 - nature.com
Once engaged by soluble or matrix-anchored ligands, cell surface proteins are commonly
sorted to lysosomal degradation through several endocytic pathways. Defective vesicular …
sorted to lysosomal degradation through several endocytic pathways. Defective vesicular …