Cancer/testis (CT) antigens are protein antigens with normal expression restricted to adult
testicular germ cells, and yet are aberrantly activated and expressed in a proportion of …

Cancer testis antigens (CTA) are a large family of tumor-associated antigens expressed in
human tumors of different histological origin, but not in normal tissues except for testis and …

Ipilimumab, a monoclonal antibody against cytotoxic T lymphocyte antigen 4 (CTLA-4), has
been shown to improve survival in patients with advanced metastatic melanoma. It also …

Cancer/testis antigens (CTAs) are named based on their expression pattern that is restricted
in a number of normal and abnormal tissues. Tumor cells frequently express antigens whose …

Cancer-testis antigens (CTAs) are considered as unique and promising cancer biomarkers
and targets for cancer therapy. CTAs are multifunctional protein group with specific …

Abstract Introduction Cancer Immunotherapy has recently emerged as a promising and
effective modality to treat different malignancies. Antigenic profiling of cancer tissues and …

CD4+ T cells are central to the function of the immune system but their role in tumor
immunity remains underappreciated. It is becoming clear that there is an enormous diversity …

T cell-mediated immunity to microbes and to cancer can be enhanced by the activation of
dendritic cells (DCs) via TLRs. In this study, we evaluated the safety and feasibility of topical …

OBJECTIVES: PRAME (Preferentially Expressed Antigen in Melanoma) is a tumor-
associated antigen recognized by immunocytes, and it induces cytotoxic T cell-mediated …

Abstract BACKGROUND: From 30% to 40% patients with osteosarcoma eventually
experience medical failure; and few biomarkers of prognostic significance have been …