The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy
Hypoxia is a non-physiological level of oxygen tension, a phenomenon common in a
majority of malignant tumors. Tumor-hypoxia leads to advanced but dysfunctional …
majority of malignant tumors. Tumor-hypoxia leads to advanced but dysfunctional …
[HTML][HTML] Functions of p38 MAP kinases in the central nervous system
Mitogen-activated protein (MAP) kinases are a central component in signaling networks in a
multitude of mammalian cell types. This review covers recent advances on specific functions …
multitude of mammalian cell types. This review covers recent advances on specific functions …
Vascular dysfunction in the pathogenesis of Alzheimer's disease—A review of endothelium-mediated mechanisms and ensuing vicious circles
Late-onset dementia is a major health concern in the ageing population. Alzheimer's
disease (AD) accounts for the largest proportion (65–70%) of dementia cases in the older …
disease (AD) accounts for the largest proportion (65–70%) of dementia cases in the older …
[HTML][HTML] Metabolic reprogramming due to hypoxia in pancreatic cancer: Implications for tumor formation, immunity, and more
X Hao, Y Ren, M Feng, Q Wang, Y Wang - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Hypoxia is a common phenomenon in most malignant tumors, especially in pancreatic
cancer (PC). Hypoxia is the result of unlimited tumor growth and plays an active role in …
cancer (PC). Hypoxia is the result of unlimited tumor growth and plays an active role in …
Asiaticoside attenuates memory impairment induced by transient cerebral ischemia–reperfusion in mice through anti-inflammatory mechanism
S Chen, ZJ Yin, C Jiang, ZQ Ma, Q Fu, R Qu… - Pharmacology …, 2014 - Elsevier
Asiaticoside (AS) is isolated from Centella asiatica (L.) which has been using for a long time
as a memory enhancing drug in India. This study was to investigate the effects of AS on …
as a memory enhancing drug in India. This study was to investigate the effects of AS on …
Effects of thyroid hormone on tissue hypoxia: relevance to sepsis therapy
AI Lourbopoulos, IS Mourouzis, AG Trikas… - Journal of Clinical …, 2021 - mdpi.com
Tissue hypoxia occurs in various conditions such as myocardial or brain ischemia and
infarction, sepsis, and trauma, and induces cellular damage and tissue remodeling with …
infarction, sepsis, and trauma, and induces cellular damage and tissue remodeling with …
[HTML][HTML] Thrombin, a mediator of cerebrovascular inflammation in AD and hypoxia
D Tripathy, A Sanchez, X Yin, J Luo… - Frontiers in aging …, 2013 - frontiersin.org
Considerable evidence implicates hypoxia and vascular inflammation in Alzheimer's
disease (AD). Thrombin, a multifunctional inflammatory mediator, is demonstrable in the …
disease (AD). Thrombin, a multifunctional inflammatory mediator, is demonstrable in the …
Hypoxia-induced signaling activation in neurodegenerative diseases: targets for new therapeutic strategies
NK Jha, SK Jha, R Sharma, D Kumar… - Journal of …, 2018 - content.iospress.com
For the maintenance of cellular homeostasis and energy metabolism, an uninterrupted
supply of oxygen (O 2) is routinely required in the brain. However, under the impaired level …
supply of oxygen (O 2) is routinely required in the brain. However, under the impaired level …
Azodyes as markers for tumor hypoxia imaging and therapy: An up-to-date review
Tumor hypoxia is the low tissue oxygen levels seen characteristically in rapidly proliferating
and expanding neoplasms. It affects both malignant tumor cells and its microenvironment …
and expanding neoplasms. It affects both malignant tumor cells and its microenvironment …
Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology
Alzheimer's disease (AD) is an aging-related neurodegenerative disease and accounts for
majority of human dementia. The hyper-phosphorylated tau-mediated intracellular …
majority of human dementia. The hyper-phosphorylated tau-mediated intracellular …