[HTML][HTML] Approaches, progress, and challenges to hepatitis C vaccine development
Risk factors for hepatitis C virus (HCV) infection vary, and there were an estimated 1.75
million new cases worldwide in 2015. The World Health Organization aims for a 90 …
million new cases worldwide in 2015. The World Health Organization aims for a 90 …
Viral quasispecies evolution
Evolution of RNA viruses occurs through disequilibria of collections of closely related mutant
spectra or mutant clouds termed viral quasispecies. Here we review the origin of the …
spectra or mutant clouds termed viral quasispecies. Here we review the origin of the …
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
TKH Scheel, CM Rice - Nature medicine, 2013 - nature.com
More than two decades of intense research has provided a detailed understanding of
hepatitis C virus (HCV), which chronically infects 2% of the world's population. This effort has …
hepatitis C virus (HCV), which chronically infects 2% of the world's population. This effort has …
Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells
B Rehermann - Nature medicine, 2013 - nature.com
Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections account for 57% of
cases of liver cirrhosis and 78% of cases of primary liver cancer worldwide and cause a …
cases of liver cirrhosis and 78% of cases of primary liver cancer worldwide and cause a …
The history of hepatitis C virus (HCV): Basic research reveals unique features in phylogeny, evolution and the viral life cycle with new perspectives for epidemic control
J Bukh - Journal of hepatology, 2016 - Elsevier
The discovery of hepatitis C virus (HCV) in 1989 permitted basic research to unravel critical
components of a complex life cycle for this important human pathogen. HCV is a highly …
components of a complex life cycle for this important human pathogen. HCV is a highly …
[HTML][HTML] Innate and adaptive immune responses in HCV infections
MH Heim, R Thimme - Journal of hepatology, 2014 - Elsevier
Hepatitis C virus has been identified a quarter of a decade ago as a leading cause of
chronic viral hepatitis that can lead to cirrhosis and hepatocellular carcinoma. Only a …
chronic viral hepatitis that can lead to cirrhosis and hepatocellular carcinoma. Only a …
Living in the liver: hepatic infections
The liver has vital metabolic and clearance functions that involve the uptake of nutrients,
waste products and pathogens from the blood. In addition, its unique immunoregulatory …
waste products and pathogens from the blood. In addition, its unique immunoregulatory …
Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence
B Rehermann - The Journal of clinical investigation, 2009 - Am Soc Clin Investig
Since the identification of the hepatitis C virus (HCV) 20 years ago, much progress has been
made in our understanding of its life cycle and interaction with the host immune system …
made in our understanding of its life cycle and interaction with the host immune system …
CD4+ T cell exhaustion revealed by high PD-1 and LAG-3 expression and the loss of helper T cell function in chronic hepatitis B
Y Dong, X Li, L Zhang, Q Zhu, C Chen, J Bao, Y Chen - BMC immunology, 2019 - Springer
Background Immune inhibitory receptors play an important role in chronic infections.
However, little is known about their role in hepatitis B virus (HBV) infection. Here, we …
However, little is known about their role in hepatitis B virus (HBV) infection. Here, we …
Immune responses to HCV and other hepatitis viruses
SH Park, B Rehermann - Immunity, 2014 - cell.com
Five human hepatitis viruses cause most of the acute and chronic liver disease worldwide.
Over the past 25 years, hepatitis C virus (HCV) in particular has received much interest …
Over the past 25 years, hepatitis C virus (HCV) in particular has received much interest …