Regulatory T (Treg) cells represent a distinct lineage of cells of the adaptive immune system
indispensable for forestalling fatal autoimmune and inflammatory pathologies. The role of …

Chemokines are small secreted proteins that orchestrate migration and positioning of
immune cells within the tissues. Chemokines are essential for the function of the immune …

Infiltration of regulatory T (Treg) cells, an immunosuppressive population of CD4+ T cells,
into solid cancers represents a barrier to cancer immunotherapy. Chemokine receptors are …

CXCR3 is a chemokine receptor with three ligands; CXCL9, CXCL10, and CXCL11.
CXCL11 binds CXCR3 with a higher affinity than the other ligands leading to receptor …

Hypertension is associated with immune cells activation and their migration into the kidney,
vasculature, heart and brain. These inflammatory mechanisms are critical for blood pressure …

G‐protein–coupled receptor (GPCR) signaling is essential for the spatiotemporal control of
leukocyte dynamics during immune responses. For efficient navigation through mammalian …

Th17 cells are most abundant in the gut, where their presence depends on the intestinal
microbiota. Here, we examined whether intestinal Th17 cells contribute to extra-intestinal …

Tissue-resident memory T (TRM) cells, functionally distinct from circulating memory T cells,
have a critical role in protective immunity in tissues, are more efficacious when elicited after …

Chemokines are a large family of small secreted proteins that have fundamental roles in
organ development, normal physiology, and immune responses upon binding to their …

The immune system is a multicentered organ that is characterized by intimate interactions
between its cellular components to efficiently ward off invading pathogens. A key constituent …