Melatonin (5‐methoxy N‐acetyltryptamine) is a hormone synthesized and released from the
pineal gland at night, which acts on specific high affinity G‐protein coupled receptors to …

Numerous physiological functions of the pineal gland hormone melatonin are mediated via
activation of two G-protein-coupled receptors, MT1 and MT2. The melatonergic drugs on the …

6 H-Isoindolo [2, 1-a] indoles (5, 7, 10, 13), 5, 6-dihydroindolo [2, 1-a] isoquinolines (20, 21),
and 6, 7-dihydro-5 H-benzo [c] azepino [2, 1-a] indoles (23, 25, 27, 30) have been prepared …

To develop a new therapeutic agent for sleep disorders, we synthesized a novel series of
tricyclic indan derivatives and evaluated them for their binding affinity to melatonin receptors …

Melatonin MT1 and MT2 receptor ligands have been vigorously explored for the last 4
decades. Inspection of approximately 80 publications in the field revealed that most …

Melatonin is a natural hormone primarily released by the pineal gland that regulates the
sleep-wake cycles. The diverse biological applications of melatonin, together with the need …

The synthesis of several novel indole melatonin analogues substituted at the 2-position with
acylaminomethyl (8− 11), acylaminoethyl (5a− k), or acylaminopropyl (13) side chains is …

For the first time, gluconic acid aqueous solution (GAAS), a biobased weakly acidic liquid,
was used as an effective promoting medium for organic reactions, such as the Michael …

The circadian nature of melatonin (MLT) secretion, coupled with the localization of MLT
receptors to the suprachiasmatic nucleus, has led to numerous studies of the role of MLT in …

Melatonin production is not restricted to the pineal gland. Several extrapineal sources of this
indole such as retina, Harderian gland, and immune system are well documented. Melatonin …