Autoreactive T cell responses have a crucial role in central nervous system (CNS) diseases
such as multiple sclerosis. Recent data indicate that CNS autoimmunity can be mediated by …

T cell epitopes represent the molecular code words through which the adaptive immune
system communicates. In the context of a T cell-mediated autoimmune disease such as type …

Introduction In spontaneous type 1 diabetes (T1D) non-obese diabetic (NOD) mice, the
insulin B chain peptide 9-23 (B: 9-23) can bind to the MHC class II molecule (IAg7) in …

Maturation of high-affinity B lymphocytes is precisely controlled during the germinal center
reaction. This is dependent on CD4+ CXCR5+ follicular helper T cells (TFH) and inhibited by …

Although multiple islet autoantigens are recognized by T lymphocytes and autoantibodies
before the development of type 1A (immune-mediated diabetes), there is increasing …

In addition to the genetic framework, there are two other critical requirements for the
development of tissue-specific autoimmune disease. First, autoreactive T cells need to …

Type 1 diabetes (T1D) results from the destruction of insulin-secreting pancreatic β cells by
autoreactive T cells. Insulin is an essential target of the autoimmune attack. Insulin epitopes …

Type 1 diabetes (T1D) is mediated by destruction of pancreatic β-cells by CD4 and CD8 T
cells specific for epitopes on numerous diabetogenic autoantigens resulting in loss of …

Type 1A diabetes is an organ-specific autoimmune disease resulting from destruction of
insulin-producing pancreatic β-cells. The main susceptibility genes code for polymorphic …

Several naturally occurring anti-insulin CD4 T cells were isolated from islet infiltrates of NOD
mice. In accordance with the results of others, these T cells recognized the segment of the β …