Impact of intracellular innate immune receptors on immunometabolism
Immunometabolism, which is the metabolic reprogramming of anaerobic glycolysis,
oxidative phosphorylation, and metabolite synthesis upon immune cell activation, has …
oxidative phosphorylation, and metabolite synthesis upon immune cell activation, has …
NOD-like receptors: versatile cytosolic sentinels
Nucleotide binding oligomerization domain (NOD)-like receptors are cytoplasmic pattern-
recognition receptors that together with RIG-I-like receptor (retinoic acid-inducible gene 1) …
recognition receptors that together with RIG-I-like receptor (retinoic acid-inducible gene 1) …
Immunometabolic rewiring of tubular epithelial cells in kidney disease
S van der Rijt, JC Leemans, S Florquin… - Nature Reviews …, 2022 - nature.com
Kidney tubular epithelial cells (TECs) have a crucial role in the damage and repair response
to acute and chronic injury. To adequately respond to constant changes in the environment …
to acute and chronic injury. To adequately respond to constant changes in the environment …
Metabolism and innate immunity meet at the mitochondria
A Bahat, T MacVicar, T Langer - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Mitochondria are master regulators of metabolism and have emerged as key signalling
organelles of the innate immune system. Each mitochondrion harbours potent agonists of …
organelles of the innate immune system. Each mitochondrion harbours potent agonists of …
[HTML][HTML] Mitochondrial protein import stress regulates the LC3 lipidation step of mitophagy through NLRX1 and RRBP1
SA Killackey, Y Bi, F Soares, I Hammi, NJ Winsor… - Molecular Cell, 2022 - cell.com
Protein import into mitochondria is a highly regulated process, yet how cells clear
mitochondria undergoing dysfunctional protein import remains poorly characterized. Here …
mitochondria undergoing dysfunctional protein import remains poorly characterized. Here …
Mitochondrial biology, targets, and drug delivery
In recent years, mitochondrial medicine has emerged as a new discipline resting at the
intersection of mitochondrial biology, pathology, and pharmaceutics. The central role of …
intersection of mitochondrial biology, pathology, and pharmaceutics. The central role of …
[HTML][HTML] Expression profile of innate immune receptors, NLRs and AIM2, in human colorectal cancer: correlation with cancer stages and inflammasome components
NLRs (nucleotide-binding domain leucine-rich repeat proteins or NOD-like receptors) are
regulators of inflammation and immunity. A subgroup of NLRs and the innate immune …
regulators of inflammation and immunity. A subgroup of NLRs and the innate immune …
Beyond the inflammasome: regulatory NOD-like receptor modulation of the host immune response following virus exposure
S Coutermarsh-Ott, K Eden… - Journal of General …, 2016 - microbiologyresearch.org
A complex interaction exists between elements of the host innate immune system and viral
pathogens. It is essential that the host mount a robust immune response during viral …
pathogens. It is essential that the host mount a robust immune response during viral …
NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity
G Stokman, L Kors, PJ Bakker, E Rampanelli… - Journal of Experimental …, 2017 - rupress.org
Mitochondrial dysfunction is the most prominent source of oxidative stress in acute and
chronic kidney disease. NLRX1 is a receptor of the innate immune system that is …
chronic kidney disease. NLRX1 is a receptor of the innate immune system that is …
NLR-dependent regulation of inflammation in multiple sclerosis
M Gharagozloo, KV Gris, T Mahvelati… - Frontiers in …, 2018 - frontiersin.org
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS)
associated with inappropriate activation of lymphocytes, hyperinflammatory responses …
associated with inappropriate activation of lymphocytes, hyperinflammatory responses …