Thrombotic thrombocytopenic purpura (TTP), a potentially fatal clinical syndrome, is
primarily caused by autoantibodies against the von Willebrand factor (VWF)‐cleaving …

ADAMTS13, and the inherited form is due to a genetic deficiency of ADAMTS13. In 1996,
Furlan and colleagues28 and Tsai29 independently found that patients with TTP had …

The metalloproteinase ADAMTS13 (a disintegrin with a thrombospondin type 1 motif,
member 13), also known as VWF (von Willebrand factor) protease, may be assessed in a …

Atypical hemolytic uremic syndrome (aHUS) is a rare, genetic, progressive, life-threatening
form of thrombotic microangiopathy (TMA) predominantly caused by dysregulation of the …

ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, 13) is a
metalloprotease responsible for cleavage of ultra-large von Willebrand factor (VWF) …

Background Thrombotic thrombocytopenic purpura (TTP) is a rare but potentially fatal
disorder caused by ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin …

ADAMTS13 is an enzyme that acts by cleaving prothrombotic von Willebrand factor (VWF)
multimers from the vasculature in a highly regulated manner. In pathologic states such as …

Targeted therapy of immune thrombotic thrombocytopenic purpura (iTTP) requires acurate
and prompt diagnosis and differentiation from complement‐mediated hemolytic uremic …

Thrombotic microangiopathy (TMA), characterized by organ injury occurring consequent to
severe endothelial damage, can manifest in a diverse range of diseases. In complement …

Thrombotic microangiopathies (TMAs) have in common a terminal phenotype of
microangiopathic hemolytic anemia with end-organ dysfunction. Thrombotic …