Estrogens and androgens influence the growth and maintenance of the mammalian
skeleton and are responsible for its sexual dimorphism. Estrogen deficiency at menopause …

Improving physical function and mobility in a continuously expanding elderly population
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …

Context: The risks of testosterone therapy in men remain poorly understood. Objective: The
aim of this study was to conduct a systematic review and meta-analyses of testosterone trials …

Aging in men is accompanied by a progressive, but individually variable decline of serum
testosterone production, more than 20% of healthy men over 60 yr of age presenting with …

Objective: The aim was to formulate practice guidelines for management of osteoporosis in
men. Evidence: We used the Grading of Recommendations, Assessment, Development, and …

Background. We performed a meta-analysis of randomized clinical trials to determine the
risks of adverse events associated with testosterone replacement in older men. Methods …

Objectives Ageing in men is associated with a gradual decline in serum testosterone levels
and a concomitant loss of muscle mass, accumulation of central adiposity, impaired mobility …

ContextHormone administration to elderly individuals can increase lean body mass (LBM)
and decrease fat, but interactive effects of growth hormone (GH) and sex steroids and their …

Background: Human growth hormone (GH) is widely used as an antiaging therapy, although
its use for this purpose has not been approved by the US Food and Drug Administration and …

Serum testosterone levels decline gradually and progressively with aging in men. Many
manifestations associated with aging in men, including muscle atrophy and weakness …