Optimization strategies of mesenchymal stem cell-based therapy for acute kidney injury

Z Fu, Y Zhang, X Geng, K Chi, C Liu, C Song… - Stem Cell Research & …, 2023 - Springer
Considering the high prevalence and the lack of targeted pharmacological management of
acute kidney injury (AKI), the search for new therapeutic approaches for it is in urgent …

Systematic review and meta‐analysis of mesenchymal stem/stromal cells therapy for impaired renal function in small animal models

Y Wang, J He, X Pei, W Zhao - Nephrology, 2013 - Wiley Online Library
Aim The meta‐analysis of recent small animal experiments of mesenchymal stem/stromal
cells (MSC) therapy for impaired kidney could provide significant clues to design large …

Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro

Y Zhou, H Xu, W Xu, B Wang, H Wu, Y Tao… - Stem cell research & …, 2013 - Springer
Introduction Administration of bone marrow mesenchymal stem cells (MSCs) or secreted
microvesicles improves recovery from acute kidney injury (AKI). However, the potential roles …

Human embryonic mesenchymal stem cell-derived conditioned medium rescues kidney function in rats with established chronic kidney disease

A van Koppen, JA Joles, BWM van Balkom, SK Lim… - PloS one, 2012 - journals.plos.org
Chronic kidney disease (CKD) is a major health care problem, affecting more than 35% of
the elderly population worldwide. New interventions to slow or prevent disease progression …

Adipose mesenchymal stem cells–derived exosomes attenuate retina degeneration of streptozotocin-induced diabetes in rabbits

A Safwat, D Sabry, A Ragiae, E Amer… - Journal of …, 2018 - journals.sagepub.com
This study aimed to evaluate the effect of mesenchymal stem cells (MSCs)–derived
exosomes in retina regeneration of experimentally induced diabetes mellitus (DM) in a …

Ischemia–reperfusion injury: beneficial effects of mesenchymal stromal cells

N Souidi, M Stolk, M Seifert - Current opinion in organ …, 2013 - journals.lww.com
MSCs show promise in protecting against IRI-induced damage. They appear to help
recovery mainly by affecting the levels of inflammation and apoptosis during the organ repair …

Intraparenchymal injection of bone marrow mesenchymal stem cells reduces kidney fibrosis after ischemia-reperfusion in cyclosporine-immunosuppressed rats

C Alfarano, C Roubeix, R Chaaya… - Cell …, 2012 - journals.sagepub.com
Ischemia-reperfusion and immunosuppressive therapy are a major cause of progressive
renal failure after kidney transplantation. Recent studies have shown that administration of …

Stem/stromal cells for treatment of kidney injuries with focus on preclinical models

A Torres Crigna, C Daniele, C Gamez… - Frontiers in …, 2018 - frontiersin.org
Within the last years, the use of stem cells (embryonic, induced pluripotent stem cells, or
hematopoietic stem cells), Progenitor cells (eg, endothelial progenitor cells), and most …

Induced pluripotent stem cells without c-Myc attenuate acute kidney injury via downregulating the signaling of oxidative stress and inflammation in ischemia …

PY Lee, Y Chien, GY Chiou, CH Lin… - Cell …, 2012 - journals.sagepub.com
Induced pluripotent stem (iPS) cells have potential for multilineage differentiation and
provide a resource for stem cell-based treatment. However, the therapeutic effect of iPS cells …

[HTML][HTML] Potential advantages of acute kidney injury management by mesenchymal stem cells

F Bianchi, E Sala, C Donadei, I Capelli… - World Journal of Stem …, 2014 - ncbi.nlm.nih.gov
Mesenchymal stem cells are currently considered as a promising tool for therapeutic
application in acute kidney injury (AKI) management. AKI is characterized by acute tubular …