Förster resonance energy transfer (FRET) has become an important tool for analyzing
different aspects of interactions among biological macromolecules in their native …

H-, N-and K-ras4B are lipid-anchored, peripheral membrane guanine nucleotide binding
proteins. Recent work has shown that Ras proteins are laterally segregated into non …

Introduction Class I cytokines regulate key processes such as growth, lactation,
hematopoiesis, and immune function and contribute to oncogenesis. Although the …

The structural elements encoding functional diversity among Ras GTPases are poorly
defined. The orientation of the G domain of H-ras with respect to the plane of the plasma …

The plasma membrane nanoscale distribution of H‐ras is regulated by guanine nucleotide
binding. To explore the structural basis of H‐ras membrane organization, we combined …

During waking behavior, animals adapt their state of arousal in response to environmental
pressures. Sensory processing is regulated in aroused states, and several lines of evidence …

Cancer stem cells (CSCs) are considered to be responsible for treatment relapse and have
therefore become a major target in cancer research. Salinomycin is the most established …

The addictive potential of opioids may be related to their differential ability to induce G
protein signaling and endocytosis. We compared the ability of 20 ligands (sampled from the …

Ras is the most frequently mutated oncogene and recent drug development efforts have
spurred significant new research interest. Here we review progress toward understanding …

Arrays of nanowires (NWs) are currently being established as vehicles for molecule delivery
and electrical-and fluorescence-based platforms in the development of biosensors. It is …