Chemotherapy resistance: Role of mitochondrial and autophagic components

E Bahar, SY Han, JY Kim, H Yoon - Cancers, 2022 - mdpi.com
Simple Summary Chemotherapy resistance is a common occurrence during cancer
treatment that cancer researchers are attempting to understand and overcome. Mitochondria …

Targeting autophagy in prostate cancer: preclinical and clinical evidence for therapeutic response

M Ashrafizadeh, MDA Paskeh, S Mirzaei… - Journal of Experimental …, 2022 - Springer
Prostate cancer is a leading cause of death worldwide and new estimates revealed prostate
cancer as the leading cause of death in men in 2021. Therefore, new strategies are pertinent …

Multiplexed organelles portrait barcodes for subcellular microRNA array detection in living cells

W Wei, H Lu, W Dai, X Zheng, H Dong - ACS nano, 2022 - ACS Publications
Multiplexed profiling of microRNAs' subcellular expression and distribution is essential to
understand their spatiotemporal function information, but it remains a crucial challenge …

Modulating Nitric Oxide: Implications for Cytotoxicity and Cytoprotection

I Belenichev, O Popazova, N Bukhtiyarova… - Antioxidants, 2024 - mdpi.com
Despite the significant progress in the fields of biology, physiology, molecular medicine, and
pharmacology; the designation of the properties of nitrogen monoxide in the regulation of life …

Mipsagargin: The beginning—Not the end—Of thapsigargin prodrug-based cancer therapeutics

JT Isaacs, WN Brennen, SB Christensen… - Molecules, 2021 - mdpi.com
Søren Brøgger Christensen isolated and characterized the cell-penetrant sesquiterpene
lactone Thapsigargin (TG) from the fruit Thapsia garganica. In the late 1980s/early 1990s …

Transient Receptor Potential Ankyrin 1 (TRPA1) Channel as a Sensor of Oxidative Stress in Cancer Cells

F Moccia, D Montagna - Cells, 2023 - mdpi.com
Moderate levels of reactive oxygen species (ROS), such as hydrogen peroxide (H2O2), fuel
tumor metastasis and invasion in a variety of cancer types. Conversely, excessive ROS …

Mitochondrial signaling pathways and their role in cancer drug resistance

A Sharma, T Virmani, G Kumar, A Sharma, R Virmani… - Cellular …, 2024 - Elsevier
Mitochondria, traditionally known as cellular powerhouses, now emerge as critical signaling
centers influencing cancer progression and drug resistance. The review highlights the role …

Exploring the relationship between autophagy and Gefitinib resistance in NSCLC by silencing PDLIM5 using ultrasound-targeted microbubble destruction technology

Y Zhang, W Lv, H Li, T Dong, H Wu, C Su, H Shu… - Cancer Cell …, 2022 - Springer
Background Ultrasound-targeted microbubble destruction (UTMD) technology is a new drug
and gene delivery strategy. This study investigates novel ultrasound (US) sensitive siRNA …

Amplifying Ca2+ Overload by Engineered Biomaterials for Synergistic Cancer Therapy

JL Liang, Y Cao, K Lv, B Xiao, J Sun - Biomaterials, 2024 - Elsevier
Ca 2+ overload is one of the most widely causes of inducing apoptosis, pyroptosis,
immunogenic cell death, autophagy, paraptosis, necroptosis, and calcification of tumor cells …

[HTML][HTML] The mechanisms of Ca2+ regulating autophagy and its research progress in neurodegenerative diseases: A review

M Hou, Z Zhang, Z Fan, L Huang, L Wang - Medicine, 2024 - journals.lww.com
Neurodegenerative diseases are complex disorders that significantly challenge human
health, with their incidence increasing with age. A key pathological feature of these diseases …