More attention is being focused on malaria today than any time since the world's last efforts
to achieve eradication over 40 years ago. The global community is now discussing …

Host-cell invasion by apicomplexan parasites is a unique process that is powered by the
gliding motility motor and requires a transmembrane link between the parasite cytoskeleton …

The continued global burden of malaria can in part be attributed to a complex lifecycle, with
both human hosts and mosquito vectors serving as transmission reservoirs. In preclinical …

Vector-borne diseases constitute an enormous burden on public health across the world.
However, despite the importance of interactions between infectious pathogens and their …

Mosquito stage, transmission blocking vaccines for malaria : Current Opinion in Infectious
Diseases Mosquito stage, transmission blocking vaccines for malaria : Current Opinion in …

Apicomplexan parasites transmitted by vectors, including Babesia spp. and Plasmodium
spp., cause severe disease in both humans and animals. These parasites have a complex …

Malaria transmission-blocking (TB) interventions are essential for malaria elimination. Small
molecules that inhibit the Plasmodium ookinete-to-oocyst transition in the midgut of …

The transformation of malaria ookinetes into oocysts occurs in the mosquito midgut and is a
major bottleneck for parasite transmission. The secreted ookinete surface protein …

To invade its definitive host, the mosquito, the malaria parasite must cross the midgut
peritrophic matrix that is composed of chitin cross-linked by chitin-binding proteins and then …

Abstract Background Two Plasmodium berghei ookinete micronemal proteins,
circumsporozoite and TRAP related protein (CTRP) and secreted ookinete adhesive protein …