Nanobody-based products as research and diagnostic tools
T De Meyer, S Muyldermans, A Depicker - Trends in biotechnology, 2014 - cell.com
Since the serendipitous discovery 20 years ago of bona fide camelid heavy-chain
antibodies, their single-domain antigen-binding fragments, known as VHHs or nanobodies …
antibodies, their single-domain antigen-binding fragments, known as VHHs or nanobodies …
[HTML][HTML] Pros and cons of different therapeutic antibody formats for recombinant antivenom development
Antibody technologies are being increasingly applied in the field of toxinology. Fuelled by
the many advances in immunology, synthetic biology, and antibody research, different …
the many advances in immunology, synthetic biology, and antibody research, different …
A comprehensive comparison between camelid nanobodies and single chain variable fragments
Y Asaadi, FF Jouneghani, S Janani… - Biomarker Research, 2021 - Springer
By the emergence of recombinant DNA technology, many antibody fragments have been
developed devoid of undesired properties of natural immunoglobulins. Among them …
developed devoid of undesired properties of natural immunoglobulins. Among them …
[HTML][HTML] Antibody fragments and their purification by protein L affinity chromatography
G Rodrigo, M Gruvegård, JM Van Alstine - Antibodies, 2015 - mdpi.com
Antibodies and related proteins comprise one of the largest and fastest-growing classes of
protein pharmaceuticals. A majority of such molecules are monoclonal antibodies; however …
protein pharmaceuticals. A majority of such molecules are monoclonal antibodies; however …
Challenges in antibody development against Tn and Sialyl-Tn antigens
The carbohydrate antigens Tn and sialyl-Tn (STn) are expressed in most carcinomas and
usually absent in healthy tissues. These antigens have been correlated with cancer …
usually absent in healthy tissues. These antigens have been correlated with cancer …
The use of nanoparticles as a promising therapeutic approach in cancer immunotherapy
M Hosseini, M Haji-Fatahaliha… - Artificial cells …, 2016 - Taylor & Francis
Cancer is one of the most important causes of death all over the world, which has not yet
been treated efficiently. Although several therapeutic approaches have been used, some …
been treated efficiently. Although several therapeutic approaches have been used, some …
PCSK9 inhibition with monoclonal antibodies: modern management of hypercholesterolemia
MK Ito, RD Santos - The Journal of Clinical Pharmacology, 2017 - Wiley Online Library
Current guidelines for hypercholesterolemia treatment emphasize lifestyle modification and
lipid‐modifying therapy to reduce the risk for cardiovascular disease. Statins are the primary …
lipid‐modifying therapy to reduce the risk for cardiovascular disease. Statins are the primary …
Production of novel recombinant anti-EpCAM antibody as targeted therapy for breast cancer
R Mirzaei, S Shafiee, R Vafaei, M Salehi, N Jalili… - International …, 2023 - Elsevier
Background The utilization of monoclonal antibodies (moAbs), an issue correlated with the
biopharmaceutical professions, is developing and maturing. Coordinated with this …
biopharmaceutical professions, is developing and maturing. Coordinated with this …
Single-chain antibody fragments: Purification methodologies
LP Malpiedi, CA Diaz, BB Nerli, A Pessoa Jr - Process Biochemistry, 2013 - Elsevier
At present, single-chain variable fragments (scFv) of antibodies are considered one of the
most important tools in human therapies. Wide applications of antibodies are being …
most important tools in human therapies. Wide applications of antibodies are being …
[HTML][HTML] Antibody fragments: Prolonging circulation half-life special issue-antibody research
AP Herrington-Symes, M Farys, H Khalili, S Brocchini - 2013 - scirp.org
Antibodies are currently the fastest growing class of therapeutic proteins. When antibody
fragments are included, there are over thirty-five antibody-based medicines approved for …
fragments are included, there are over thirty-five antibody-based medicines approved for …