Nanobody-based products as research and diagnostic tools

T De Meyer, S Muyldermans, A Depicker - Trends in biotechnology, 2014 - cell.com
Since the serendipitous discovery 20 years ago of bona fide camelid heavy-chain
antibodies, their single-domain antigen-binding fragments, known as VHHs or nanobodies …

[HTML][HTML] Pros and cons of different therapeutic antibody formats for recombinant antivenom development

AH Laustsen, JM Gutiérrez, C Knudsen, KH Johansen… - Toxicon, 2018 - Elsevier
Antibody technologies are being increasingly applied in the field of toxinology. Fuelled by
the many advances in immunology, synthetic biology, and antibody research, different …

A comprehensive comparison between camelid nanobodies and single chain variable fragments

Y Asaadi, FF Jouneghani, S Janani… - Biomarker Research, 2021 - Springer
By the emergence of recombinant DNA technology, many antibody fragments have been
developed devoid of undesired properties of natural immunoglobulins. Among them …

[HTML][HTML] Antibody fragments and their purification by protein L affinity chromatography

G Rodrigo, M Gruvegård, JM Van Alstine - Antibodies, 2015 - mdpi.com
Antibodies and related proteins comprise one of the largest and fastest-growing classes of
protein pharmaceuticals. A majority of such molecules are monoclonal antibodies; however …

Challenges in antibody development against Tn and Sialyl-Tn antigens

LR Loureiro, MA Carrascal, A Barbas, JS Ramalho… - Biomolecules, 2015 - mdpi.com
The carbohydrate antigens Tn and sialyl-Tn (STn) are expressed in most carcinomas and
usually absent in healthy tissues. These antigens have been correlated with cancer …

The use of nanoparticles as a promising therapeutic approach in cancer immunotherapy

M Hosseini, M Haji-Fatahaliha… - Artificial cells …, 2016 - Taylor & Francis
Cancer is one of the most important causes of death all over the world, which has not yet
been treated efficiently. Although several therapeutic approaches have been used, some …

PCSK9 inhibition with monoclonal antibodies: modern management of hypercholesterolemia

MK Ito, RD Santos - The Journal of Clinical Pharmacology, 2017 - Wiley Online Library
Current guidelines for hypercholesterolemia treatment emphasize lifestyle modification and
lipid‐modifying therapy to reduce the risk for cardiovascular disease. Statins are the primary …

Production of novel recombinant anti-EpCAM antibody as targeted therapy for breast cancer

R Mirzaei, S Shafiee, R Vafaei, M Salehi, N Jalili… - International …, 2023 - Elsevier
Background The utilization of monoclonal antibodies (moAbs), an issue correlated with the
biopharmaceutical professions, is developing and maturing. Coordinated with this …

Single-chain antibody fragments: Purification methodologies

LP Malpiedi, CA Diaz, BB Nerli, A Pessoa Jr - Process Biochemistry, 2013 - Elsevier
At present, single-chain variable fragments (scFv) of antibodies are considered one of the
most important tools in human therapies. Wide applications of antibodies are being …

[HTML][HTML] Antibody fragments: Prolonging circulation half-life special issue-antibody research

AP Herrington-Symes, M Farys, H Khalili, S Brocchini - 2013 - scirp.org
Antibodies are currently the fastest growing class of therapeutic proteins. When antibody
fragments are included, there are over thirty-five antibody-based medicines approved for …