Mammalian models including non‐human primates, pigs and rodents have been used
extensively to study the mechanisms of cardiovascular disease. However, there is an …

Apart from acute and chronic blood pressure lowering, we have no specific medications to
prevent intracerebral haemorrhage (ICH) or improve outcomes once bleeding has occurred …

Danionella cerebrum is a new vertebrate model that offers an exciting opportunity to
visualize dynamic biological processes in intact adult animals. Key advantages of this model …

RNASET2-deficient leukodystrophy is a rare infantile white matter disorder mimicking a viral
infection and resulting in severe psychomotor impairments. Despite its severity, there is little …

Aicardi-Goutières syndrome (AGS1-9) is a genetically determined encephalopathy that falls
under the type I interferonopathy disease class, characterized by excessive type I interferon …

Despite the global health burden, treatment of spontaneous intracerebral haemorrhage
(ICH) is largely supportive, and translation of specific medical therapies has not been …

We describe a straightforward, scalable method for administering traumatic brain injury (TBI)
to zebrafish larvae. The pathological outcomes appear generalizable for all TBI types, but …

There has been rapid growth in the use of larval zebrafish as a complementary vertebrate
model for drug discovery, abuse liability and pharmacological toxicology, resulting in a huge …

Hemorrhage stroke is a severe vascular disease of the brain with a high mortality rate in
humans. Salvia miltiorrhiza Bunge (Danshen) is a well-known Chinese Materia Medica for …

Airy light-sheet microscopy is rapidly gaining importance for imaging intact biological
specimens because of the rapid speed, high resolution, and wide field nature of the imaging …