The prefrontal cortex (PFC) is not only important in executive functions, but also pain
processing. The latter is dependent on its connections to other areas of the cerebral …

Neuropathic pain is a pathological condition induced by a lesion or disease affecting the
somatosensory system, with symptoms like allodynia and hyperalgesia. It has a multifaceted …

Chronic neurodegenerative diseases represent major unmet needs for therapeutic
interventions. Recently, the neurocentric view of brain function and disease has been …

Chronic pain is associated with long term plasticity of nociceptive pathways in the central
nervous system. Astrocytes can profoundly affect synaptic function and increasing evidence …

Background and Purpose Patients suffering from trigeminal neuralgia are often
accompanied by anxiety and depression. Microglia‐mediated neuroinflammation is involved …

Dysfunction of glutamatergic synaptic plasticity in basolateral amygdala (BLA) constitutes a
critical pathogenic mechanism underlying the depression-like behaviors induced by chronic …

Neuronal differentiation involves extensive modification of biochemical and morphological
properties to meet novel functional requirements. Reorganization of the mitochondrial …

The complexity of neuronal networks cannot only be explained by neuronal activity so
neurobiological research in the last decade has focused on different components of the …

Neuro-immune interactions contribute to the pathogenesis of neuropathic pain due to
peripheral nerve injury. A large body of preclinical evidence supports the idea that the …

Patients with neuropathic pain induced by nerve injury usually present with co-morbid
affective changes, such as depression. Neuroglia was reported to play an important role in …