Sickle cell disease and β-thalassaemia are inherited haemoglobinopathies resulting in
structural and quantitative changes in the β-globin chain. These changes lead to instability …

As essential mediators of red cell production, erythropoietin (EPO) and its cell surface
receptor (EPO receptor [EPOR]) have been intensely studied. Early investigations defined …

Iron overload and iron toxicity, whether because of increased absorption or iron loading from
repeated transfusions, can be major causes of morbidity and mortality in a number of chronic …

Anemia in β-thalassemia is related to ineffective erythropoiesis and reduced red cell
survival. Excess free heme and accumulation of unpaired α-globin chains impose …

Sickle cell disease (SCD) is an inherited monogenic disorder and the most common severe
hemoglobinopathy in the world. SCD is characterized by a point mutation in the β-globin …

Abstract Band 3 protein (B3p), anion transporter, allows the HCO3−/Cl− exchange across
plasma membrane and plays an important role for erythrocytes homeostasis. In addition …

A significant amount of attention has recently been devoted to the mechanisms involved in
hemoglobin (Hb) switching, as it has previously been established that the induction of fetal …

Red blood cells (RBC) are specifically differentiated to transport oxygen and carbon dioxide
in the blood and they lack most organelles, including mitochondria. The autoxidation of …

Aging, a time‐dependent multifaceted process, affects both cell structure and function and
involves oxidative stress as well as glycation. The present investigation focuses on the role …

β-thalassaemia is a rare genetic condition caused by mutations in the β-globin gene that
result in severe iron-loading anaemia, maintained by a detrimental state of ineffective …