Cytokine storm syndrome (CSS) has generally been described as a collection of clinical
manifestations resulting from an overactivated immune system. Cytokine storms (CSs) are …

Hemophagocytic lymphohistiocytosis is a life-threatening disorder characterized by
unbridled activation of cytotoxic T lymphocytes, natural killer (NK) cells, and macrophages …

Hemophagocytic lymphohistiocytosis (HLH) covers a wide array of related life-threatening
conditions featuring ineffective immunity characterized by an uncontrolled …

In HLH‐94, the first prospective international treatment study for hemophagocytic
lymphohistiocytosis (HLH), diagnosis was based on five criteria (fever, splenomegaly …

Perforin/granzyme-induced apoptosis is the main pathway used by cytotoxic lymphocytes to
eliminate virus-infected or transformed cells. Studies in gene-disrupted mice indicate that …

Hemophagocytic lymphohistiocytosis (HLH) is a frequently fatal and likely underdiagnosed
disease involving a final common pathway of hypercytokinemia, which can result in end …

Hemophagocytic lymphohistiocytosis (HLH) comprises familial (primary) hemophagocytic
lymphohistiocytosis (FHL) and secondary HLH (SHLH), both clinically characterized by …

Virtually all of the measurable cell-mediated cytotoxicity delivered by cytotoxic T
lymphocytes and natural killer cells comes from either the granule exocytosis pathway or the …

Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder with familial and acquired
forms. The familial form is associated with mutations in the perforin gene and both forms are …

Genetic variations resulting in a change of amino acid sequence can have a dramatic effect
on stability, hydrogen bond network, conformational dynamics, activity and many other …