Asthma is a globally significant non-communicable disease with major public health
consequences for both children and adults, including high morbidity, and mortality in severe …

Asthma treatment goals currently focus on symptom and exacerbation control rather than
remission. Remission is not identical to cure, but is a step closer. This review considers the …

Executive summary Asthma is responsible for considerable global morbidity and health-care
costs. Substantial progress was made against key outcomes such as hospital admissions …

Background Chronic obstructive pulmonary disease (COPD) is thought to result from an
accelerated decline in forced expiratory volume in 1 second (FEV1) over time. Yet it is …

The normal lung function trajectory from birth to death has three phases: a growth phase
(from birth to early adulthood), a plateau phase (that lasts for a few years), and a decline …

Background Tracking longitudinal measurements of growth and decline in lung function in
patients with persistent childhood asthma may reveal links between asthma and subsequent …

Asthma varies considerably across the life course. Childhood asthma is known for its overall
high prevalence with a male predominance prior to puberty, common remission, and rare …

Early-Life Origins of Chronic Obstructive Pulmonary Disease | New England Journal of Medicine
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Chronic obstructive pulmonary disease is mainly a smoking-related disorder and affects
millions of people worldwide, with a large effect on individual patients and society as a …

Background Maximal lung function in early adulthood is an important determinant of
mortality and COPD. We investigated whether distinct trajectories of lung function are …