Globally, migraine is a leading cause of disability with a huge impact on both the work and
private life of affected persons. To overcome the societal migraine burden, better treatment …

Migraine is one of the leading causes of disability worldwide, affecting work and social life. It
has been estimated that sales of migraine medicines will reach 12.9 billion USD in 2027. To …

Background Chronic migraine is a common and highly disabling disorder. Functional MRI
has indicated that abnormal brain region activation is linked with chronic migraine. Drugs …

Background Migraine headache attacks and accompanying sensory augmentation can be
induced by several agents including levcromakalim (LVC), that is also capable of provoking …

Migraine, a primary headache disorder involving a dysfunctional trigeminal vascular system,
remains a major debilitating neurological condition impacting many patients' quality of life …

Migraine is a leading cause of disability worldwide. Despite the recent approval of several
calcitonin gene-related peptide-targeted therapies, many people with migraine do not …

Migraine is a pervasive neurologic disease closely related to neurogenic inflammation. The
astrocytes and microglia in the central nervous system are vital in inducing neurogenic …

Migraine is a highly disabling pain disorder with huge socioeconomic and personal costs. It
is genetically heterogenous leading to variability in response to current treatments and …

Background GABA, a key inhibitory neurotransmitter, has synaptic and extrasynaptic
receptors on the postsynaptic neuron. Background GABA, which spills over from the synaptic …

Objective To investigate the role of NN414, a selective KATP channel opener for the Kir6.
2/SUR1 channel subtype found in neurons and β-pancreatic cells, in inducing migraine …