The potential for ischemic preconditioning to reduce infarct size was first recognized more
than 30 years ago [180]. Despite extension of the concept to ischemic postcondition‑ing …

1. Introduction duction, but that the impaired flow also results in impaired removal of
metabolic waste products. In the large majority Although myocardial ischaemia has been …

To define the relationship between infarct size and ventricular performance, we performed
hemodynamic studies in rats 21 days after left coronary artery occlusion. Ventricular …

Adaptive changes to oxygen availability are critical for cell survival and tissue homeostasis.
Prolonged oxygen deprivation due to reduced blood flow to cardiac or peripheral tissues …

Background Pyroptosis and oxidative stress play pivotal roles in cardiomyocyte loss after
myocardial infarction. NF-κB is associated with oxidative stress and gasdermin D (GSDMD) …

Antioxidant enzyme activities and oxidative stress were evaluated in the myocardium in
relation to hemodynamic function subsequent to myocardial infarction in rats. One week after …

Surgical occlusion of the left coronary artery of the rat is a relatively simple, economical
technique for producing experimental myocardial infarction (MI). Histologic study of 1-to 21 …

Very early reperfusion after coronary occlusion can reduce infarct size and preserve left
ventricular function. Whether later reperfusion is of benefit is unclear. We studied the effect of …

Expansion (regional dilatation and thinning) of acutely infarcted myocardium in man has
been shown to correlate with overall cardiac dilatation and rupture. We studied gross and …

Aquaporin-2 (AQP2) mediates vasopressin-regulated collecting duct water permeability.
Chronic heart failure (CHF) is characterized by abnormal renal water retention. We …