Modern medicine has been waging a war on cancer for nearly a century with no tangible
end in sight. Cancer treatments have significantly progressed, but the need to increase …

Chemotherapy is a well-known and effective treatment for different cancers; unfortunately, it
has not been as efficient in the eradication of all cancer cells as been expected. The …

The human gastrointestinal tract is inhabited by a vast number of microorganisms that are
called as the microbiota. Each individual harbors a unique gut microbial composition, this …

Aging is a major risk factor for a number of chronic diseases, including neurodegenerative
and cerebrovascular disorders. Aging processes have therefore been discussed as potential …

Colorectal cancer (CRC) therapy using conventional chemotherapeutics represents a
considerable burden for the patient's organism because of high toxicity while the response is …

In order to maintain genomic stability, cells have developed sophisticated signalling
pathways to enable DNA damage or DNA replication stress to be resolved. Key mediators of …

The repair of DNA damage is a complex process that relies on particular pathways to
remedy specific types of damage to DNA. The range of insults to DNA includes small …

Simple Summary Internationally, in women, breast cancer (BC) is the most common cancer
type and is the leading cause of cancer-related death. There are two main histological …

Tumor cells undergo senescence in response to both conventional and targeted cancer
therapies. The induction of senescence in response to cancer therapy can contribute to …

The DNA damage response (DDR) is now known to play an important role in both cancer
development and its treatment. Targeting proteins such as ATR (Ataxia telangiectasia …