Global protein dynamics as communication sensors in peptide synthetase domains

SH Mishra, AK Kancherla, KA Marincin… - Science …, 2022 - science.org
Biological activity is governed by the timely redistribution of molecular interactions, and static
structural snapshots often appear insufficient to provide the molecular determinants that …

Decoding Atomic Addresses: Solution NMR Resonance Assignment of Proteins

T Viennet, A Dubey, R Törner, MA Droemer, P Coote… - 2023 - books.rsc.org
Resonance assignment signifies the process through which an NMR signal at a certain
resonance frequency, or chemical shift, is correlated to a specific atom in a protein. The …

In-cell Structural Biology Through the Integration of Solution NMR Spectroscopy and Computational Science

Y Ito, T Ikeya, K Inomata - 2023 - books.rsc.org
The intracellular environment is highly crowded (molecular crowding) and differs
significantly from the environment in dilute solutions that we usually use in biochemical …

EXPLORING MUTAGENESIS AND DEVELOPING NOVEL NUCLEAR MAGNETIC RESONANCE TECHNIQUES TO STUDY NONRIBOSOMAL PEPTIDE …

KA Marincin - 2023 - jscholarship.library.jhu.edu
Nonribosomal peptide synthetases (NRPSs) are a class of enzymes that produce complex
natural products with applications in medicine and industry. Their modular architecture is …