Staphylococcus aureus is a common cause of both superficial and invasive infections of
humans and animals. Despite a potent host response and apparently appropriate antibiotic …

Many important cellular processes are performed by molecular machines, composed of
multiple proteins that physically interact to execute biological functions. An example is the …

Nisin is applied as a food preservative in processed foods and has the potential to be used
synergistically with antibiotics for treatment of patients infected by antibiotic-resistant …

Combining antibiotics with resistance reversing agents is a key strategy to overcome
bacterial resistance. Upon screening antimicrobial activities of plants used in traditional …

We have developed GmPcides from a peptidomimetic dihydrothiazolo ring-fused 2-pyridone
scaffold that has antimicrobial activities against a broad spectrum of Gram-positive …

Abstract Background The human pathogen Streptococcus pyogenes, or group A
Streptococcus, is responsible for mild infections to life-threatening diseases. To facilitate the …

Recently, we presented a whole-cell kinetic model of the genetically minimal bacterium JCVI-
syn3A that described the coupled metabolic and genetic information processes and …

We have optimized a clustered regularly interspaced short palindromic repeat (CRISPR)
interference system to facilitate gene knockdown in the Gram-positive bacterial pathogen …

Abstract β-lactam antibiotics target penicillin-binding proteins (PBPs) preventing
peptidoglycan synthesis and this inhibition is circumvented in methicillin resistant …

Cervimycins A–D are bis-glycosylated polyketide antibiotics produced by Streptomyces
tendae HKI 0179 with bactericidal activity against Gram-positive bacteria. In this study …