Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) stand as the prevailing
sources of neurodegenerative dementia, impacting over 55 million individuals across the …

Background Vascular dementia (VD) is the second most common type of dementia after
Alzheimer's disease. β-asarone, a major component of Acorus tatarinowii Schott, is …

Background Chronic cerebral hypoperfusion (CCH) is a frequently observed underlying
pathology of both Alzheimer's disease (AD) and vascular dementia (VD), which is a common …

Macroautophagy, herein referred to as autophagy, has long been implicated in the
pathophysiology of neurodegenerative diseases. However, an incomplete understanding of …

Dysfunctional autophagy and impairment of adult hippocampal neurogenesis (AHN) each
contribute to the pathogenesis of major depressive disorder (MDD). However, whether …

Autophagy is a conserved, catabolic process essential for maintaining cellular homeostasis.
Malfunctional autophagy contributes to neurodevelopmental and neurodegenerative …

Intracellular signaling dynamics play a crucial role in cell function. Protein kinase A (PKA) is
a key signaling molecule that has diverse functions, from regulating metabolism and brain …

Abstract Chromogranin A (CgA), a∼ 49 kDa acidic secretory protein, is ubiquitously
distributed in endocrine and neuroendocrine cells and neurons. As a propeptide, CgA is …

Background Zinc oxide nanoparticles (ZnO NPs) has been widely used in various fields and
has had an important impact on human public health. In addition, it inevitably damages …

Brain homeostasis refers to the normal working state of the brain in a certain period, which is
important for overall health and normal life activities. Currently, there is a lack of effective …