This manuscript represents a review of lymphoblastic leukemia/lymphoma (acute
lymphoblastic leukemia/lymphoblastic lymphoma), acute leukemias of ambiguous lineage …

Current single-cell RNA-sequencing approaches have limitations that stem from the
microfluidic devices or fluid handling steps required for sample processing. We develop a …

Genomic analyses have revolutionized our understanding of the biology of B-progenitor
acute lymphoblastic leukemia (ALL). Studies of thousands of cases across the age spectrum …

Identifying the causes of human diseases requires deconvolution of abnormal molecular
phenotypes spanning DNA accessibility, gene expression and protein abundance,–. We …

Allosteric inhibitors of mutant IDH1 or IDH2 induce terminal differentiation of the mutant
leukemic blasts and provide durable clinical responses in approximately 40% of acute …

Acute leukemias (ALs) of ambiguous lineage are a heterogeneous group of high-risk
leukemias characterized by coexpression of myeloid and lymphoid markers. In this study, we …

The International Consensus Classification of Myeloid and Lymphoid Neoplasms is the
result of the findings of a clinical advisory committee (CAC) meeting with involvement by an …

Abstract Purpose of Review Mixed phenotype acute leukemia (MPAL) is a rare subtype of
acute leukemia with features of both acute lymphoblastic leukemia (ALL) and acute myeloid …

Abstract KMT2A rearranged (KMT2A r) acute lymphoblastic leukaemia (ALL) is a high-risk
genomic subtype, with long-term survival rates of less than 60% across all age groups …

Mixed phenotype acute leukemias (MPALs) represent a rare subgroup of acute leukemias
with a poor prognosis. Proper diagnosis and classification of MPAL is extremely important …