Genomes of all living organisms are constantly threatened by endogenous and exogenous
agents that challenge the chemical integrity of DNA. Most bacteria have evolved a …

The presence of an abnormal amount of single-stranded DNA in the bacterial cell constitutes
a genotoxic alarm signal that induces the SOS response, a broad regulatory network found …

Recent studies indicate that a subclass of APOBEC cytidine deaminases, which convert
cytosine to uracil during RNA editing and retrovirus or retrotransposon restriction, may …

The replication-stress response enables the DNA replication machinery to overcome DNA
lesions or intrinsic replication-fork obstacles, and it is essential to ensure faithful …

Genomes are transmitted faithfully from dividing cells to their offspring. Changes that occur
during DNA repair, chromosome duplication, and transmission or via recombination provide …

Genomic instability in the form of mutations and chromosome rearrangements is usually
associated with pathological disorders, and yet it is also crucial for evolution. Two types of …

When describing the structure of the DNA double helix, Watson and Crick (1) wrote,“It has
not escaped our notice that the specific pairing we have postulated immediately suggests a …

▪ Abstract The process of homologous recombination promotes error-free repair of double-
strand breaks and is essential for meiosis. Central to the process of homologous …

DNA damage can stall the DNA replication machinery, leading to genomic instability. Thus,
numerous mechanisms exist to complete genome duplication in the absence of a pristine …

DNA replication forks pause in front of lesions on the template, eventually leading to
cytotoxic chromosomal rearrangements. The in vivo structure of damaged eukaryotic …