Biofilms as promoters of bacterial antibiotic resistance and tolerance

C Uruén, G Chopo-Escuin, J Tommassen… - Antibiotics, 2020 - mdpi.com
Multidrug resistant bacteria are a global threat for human and animal health. However, they
are only part of the problem of antibiotic failure. Another bacterial strategy that contributes to …

[HTML][HTML] The microbiota of the respiratory tract: gatekeeper to respiratory health

WH Man, WAA de Steenhuijsen Piters… - Nature Reviews …, 2017 - nature.com
The respiratory tract is a complex organ system that is responsible for the exchange of
oxygen and carbon dioxide. The human respiratory tract spans from the nostrils to the lung …

Early respiratory microbiota composition determines bacterial succession patterns and respiratory health in children

G Biesbroek, E Tsivtsivadze, EAM Sanders… - American journal of …, 2014 - atsjournals.org
Rationale: Many bacterial pathogens causing respiratory infections in children are common
residents of the respiratory tract. Insight into bacterial colonization patterns and microbiota …

From in vitro to in vivo Models of Bacterial Biofilm-Related Infections

D Lebeaux, A Chauhan, O Rendueles, C Beloin - Pathogens, 2013 - mdpi.com
The influence of microorganisms growing as sessile communities in a large number of
human infections has been extensively studied and recognized for 30–40 years, therefore …

Polymicrobial interactions: impact on pathogenesis and human disease

BM Peters, MA Jabra-Rizk, GA O'May… - Clinical microbiology …, 2012 - Am Soc Microbiol
Microorganisms coexist in a complex milieu of bacteria, fungi, archaea, and viruses on or
within the human body, often as multifaceted polymicrobial biofilm communities at mucosal …

[HTML][HTML] Manipulation of the quorum sensing signal AI-2 affects the antibiotic-treated gut microbiota

JA Thompson, RA Oliveira, A Djukovic, C Ubeda… - Cell reports, 2015 - cell.com
The mammalian gut microbiota harbors a diverse ecosystem where hundreds of bacterial
species interact with each other and their host. Given that bacteria use signals to …

AI-2-mediated signalling in bacteria

CS Pereira, JA Thompson… - FEMS microbiology …, 2013 - academic.oup.com
Success in nature depends upon an ability to perceive and adapt to the surrounding
environment. Bacteria are not an exception; they recognize and constantly adjust to …

Options and limitations in clinical investigation of bacterial biofilms

M Magana, C Sereti, A Ioannidis… - Clinical Microbiology …, 2018 - Am Soc Microbiol
Bacteria can form single-and multispecies biofilms exhibiting diverse features based upon
the microbial composition of their community and microenvironment. The study of bacterial …

Quorum sensing for population-level control of bacteria and potential therapeutic applications

S Wu, J Liu, C Liu, A Yang, J Qiao - Cellular and Molecular Life Sciences, 2020 - Springer
Quorum sensing (QS), a microbial cell-to-cell communication process, dynamically regulates
a variety of metabolism and physiological activities. In this review, we provide an update on …

“It takes a village”: mechanisms underlying antimicrobial recalcitrance of polymicrobial biofilms

G Orazi, GA O'Toole - Journal of Bacteriology, 2019 - Am Soc Microbiol
Chronic infections are frequently caused by polymicrobial biofilms. Importantly, these
infections are often difficult to treat effectively in part due to the recalcitrance of biofilms to …