Aging is the greatest risk factor for late-onset Alzheimer's disease (LOAD), which accounts
for> 95% of Alzheimer's disease (AD) cases. The mechanism underlying the aging-related …

Increased cerebrovascular amyloid-β (Aβ) deposition represents the main pathogenic
mechanisms characterizing Alzheimer's disease (AD) and cerebral amyloid angiopathy …

Cellular senescence contributes importantly to aging and aging-related diseases, including
idiopathic pulmonary fibrosis (IPF). Alveolar epithelial type II (ATII) cells are progenitors of …

The etiology for late-onset Alzheimer's disease (LOAD), which accounts for> 95% of
Alzheimer's disease (AD) cases, is unknown. Emerging evidence suggests that cellular …

Background There is an urgent need for cost-effective, easy-to-measure biomarkers to
identify subjects who will develop Alzheimer's disease (AD), especially at the pre …

Vascular Dementia (VaD) is a neurocognitive disorder caused by reduced blood flow to the
brain tissue, resulting in infarction, and is the second most common type of dementia. The …

Elucidating the pathogenic mechanisms of Alzheimer's disease (AD) to identify therapeutic
targets has been the focus of many decades of research. While deposition of extracellular …

In recent years, increasing attention has been paid to research on diseases related to the
deposition of misfolded proteins (amyloids) in various organs. Moreover, modern scientists …

Background Alzheimer's disease (AD) is the leading cause of dementia worldwide; however,
the molecular mechanisms underlying its pathogenesis remain unclear. The present study …

Background and objectives There is a scarcity of data stemming from large-scale
epidemiological longitudinal studies focusing on potentially preventable and controllable …