Circulation of cerebrospinal fluid and interstitial fluid around the central nervous system and
through the brain transports not only those water-like fluids but also any solutes they carry …

The process of aging includes changes in cellular biology that affect local interactions
between cells and their environments and eventually propagate to systemic levels. In the …

Energy use limits the information processing power of the brain. However, apart from the
ATP used to power electrical signalling, a significant fraction of the brain's energy …

The human brain constitutes 2% of the body's total mass but uses 20% of the oxygen. The
rate of the brain's oxygen utilization can be derived from a knowledge of cerebral blood flow …

The BOLD contrast mechanism has a complex relationship with functional brain activity,
oxygen metabolism, and neurovascular factors. Accurate interpretation of the BOLD signal …

Despite the possible role of impaired cerebral tissue oxygenation in age-related cognition
decline, much is still unknown about the changes in brain tissue pO2 with age. Using a …

Prior studies of aging and Alzheimer disease have evaluated resting state functional
connectivity (FC) using either seed-based correlation (SBC) or independent component …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

As the world ages, it becomes urgent to unravel the mechanisms underlying brain aging and
find ways of intervening with them. While for decades cognitive aging has been related to …

Purpose Many brain diseases are associated with an alteration in blood‐brain barrier (BBB)
and its permeability. Current methods using contrast agent are primarily sensitive to major …