KRAS is the most frequently mutated oncogene in human cancer. In addition to holding this
distinction, unsuccessful attempts to target this protein have led to the characterization of …

Ras proteins are classical members of small GTPases that function as molecular switches by
alternating between inactive GDP-bound and active GTP-bound states. Ras activation is …

A novel method for differentiating between correctly and incorrectly determined regions of
protein structures based on characteristic atomic interactions is described. Different types of …

AS methods for determining protein three-dimensional (3D) structure develop, a continuing
problem is how to verify that the final protein model is correct. The revision of several protein …

Although the roots of Ras sprouted from the rich history of retrovirus research, it was the
discovery of mutationally activated RAS genes in human cancer in 1982 that stimulated an …

From the pioneering work with acute transforming retroviruses to the current post-genomic
era, RAS genes have always been at the leading edge of signal transduction and molecular …

GTPases are conserved molecular switches, built according to a common structural design.
Rapidly accruing knowledge of individual GTPases—crystal structures, biochemical …

Ras proteins participate as a molecular switch in the early steps of the signal transduction
pathway that is associated with cell growth and differentiation. When the protein is in its GTP …

Ras proteins play a crucial role as a central component of the cellular networks controlling a
variety of signaling pathways that regulate growth, proliferation, survival, differentiation …

A set of 11 clones encoding putative GTP binding proteins highly homqlogous to the yeast
YP7Y/SEC4 gene products have been isolated from an MDCK cell cDNA library. We …