Immunotherapy has emerged as a promising treatment paradigm for many malignancies
and is transforming the drug development landscape. Although immunotherapeutic agents …

The hepatitis E virus (HEV) was initially thought to exclusively cause acute hepatitis.
However, the first diagnosis of chronic hepatitis E in transplant recipients in 2008 profoundly …

Mice xenotransplanted with human cells and/or expressing human gene products (also
known as “humanized mice”) recapitulate the human evolutionary specialization and …

Human innate immunity plays a critical role in tumor surveillance and in immunoregulation
within the tumor microenvironment. Natural killer (NK) cells are innate lymphoid cells that …

Human induced pluripotent stem cells (iPSCs) can be limitlessly expanded and
differentiated into almost all cell types. Moreover, they are amenable to gene manipulation …

As medical and pharmacological technology advances, new and complex modalities of
disease treatment that are more personalized and targeted are being developed. Often …

Chronic hepatitis B virus (HBV) infection affects more than 250 million people worldwide,
which greatly increases the risk for terminal liver diseases, such as liver cirrhosis and …

The human immunological mechanisms defining the clinical outcome of SARS-CoV-2
infection remain elusive. This knowledge gap is mostly driven by the lack of appropriate …

The development of mouse models of human disease and synthetic biology research by
targeted transgenesis of large DNA constructs represent a significant genetic engineering …

Immunotherapy has revolutionized cancer treatment, however, not all tumor types and
patients are completely responsive to this approach. Establishing predictive pre‐clinical …