Myeloid neoplasms, including acute myeloid leukemia (AML), myeloproliferative neoplasms
(MPNs), and myelodysplastic syndromes (MDS), feature clonal dominance and remodeling …

Ethanol misuse is frequently associated with a multitude of profound medical conditions,
contributing to health-, individual-and social-related damage. A particularly dangerous threat …

Despite evidence of chronic inflammation in myelodysplastic syndrome (MDS) and cell-
intrinsic dysregulation of Toll-like receptor (TLR) signaling in MDS hematopoietic stem and …

A20 is a potent anti-inflammatory protein, acting by inhibiting nuclear factor κB (NF-κB)
signaling and inflammatory gene expression and/or by preventing cell death. Mutations in …

Deubiquitylating enzymes (DUBs) are proteases that remove the ubiquitin moiety from
ubiquitylated substrates to antagonize the modification mediated by E3 ubiquitin ligases …

Basal nuclear factor κB (NF-κB) activation is required for hematopoietic stem cell (HSC)
homeostasis in the absence of inflammation; however, the upstream mediators of basal NF …

The coordination between cellular differentiation and the mesenchymal/stem transition is
essential for both embryo development and neoplasia, suggesting a mechanistic link …

Constitutive activation of the canonical NF-κB pathway has been associated with a variety of
human pathologies. However, molecular mechanisms through which canonical NF-κB …

The status of long-term quiescence and dormancy guarantees the integrity of hematopoietic
stem cells (HSCs) during adult homeostasis. However the molecular mechanisms regulating …

Identifying physiological roles of specific signaling pathways that regulate hematopoietic
stem cell (HSC) functions may lead to new treatment strategies and therapeutic interventions …