Exosomes are well-known key mediators of intercellular communication and contribute to
various physiological and pathological processes. Their biogenesis involves four key steps …

Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Exosomes are extracellular vesicles (EVs) that are secreted into body fluids by multiple cell
types and are enriched in bioactive molecules, although their exact contents depend on the …

Multiple myeloma (MM) is a highly heterogenous disease that exists along a continuous
disease spectrum starting with premalignant conditions monoclonal gammopathy of …

Exosomes secreted by bone marrow mesenchymal stem cells (BMSCs) promote
osteosarcoma cell proliferation and migration, while the underlying mechanism remains …

The acetylation of histone and non-histone proteins has been implicated in several disease
states. Modulation of such epigenetic modifications has therefore made histone …

Abstract Background Histone deacetylases (HDACs) are believed to exacerbate traumatic
brain injury (TBI) based on studies using pan-HDAC inhibitors. However, the HDAC isoform …

Background The immune environment of lung cancer is complex, and the critical immune
factors that promote lung cancer progression need to be explored. Granulocytic myeloid …

Simple Summary Multiple Myeloma (MM) is a blood cancer characterized by an uncontrolled
growth of cells named plasma cells, within the bone marrow. Patients with MM may present …

Multiple myeloma (MM) cells derive proliferative signals from the bone marrow (BM)
microenvironment via exosomal crosstalk. Therapeutic strategies targeting this crosstalk are …