The molecules of Major histocompatibility class I (MHC-I) load peptides and present them on
the cell surface, which provided the immune system with the signal to detect and eliminate …

Epithelial–mesenchymal transition (EMT) is a dynamic program crucial for organismal
development and tissue regeneration. Unfortunately, this program is often hijacked by …

Abstract Background Glioblastomas (GBMs) are central nervous system tumors that resist
standard-of-care interventions and even immune checkpoint blockade. Myeloid cells in the …

NKG2D is an activating receptor of natural killer cells that recognizes stress-induced ligands
(NKG2DL) expressed by many tumor cells. Nevertheless, NKG2DL downregulation or …

Abstract Purpose: Interleukin-2 and-12 cytokines have potent anti-cancer activity, but suffer a
narrow therapeutic window due to off-tumor immune cell activation. Engineering cytokines …

With the recent advances in neoantigen identification, peptide-based cancer vaccines offer
substantial potential in the field of immunotherapy. However, rapid clearance, low …

Extracellular vesicles (EVs) are important mediators of communication between cells. Here,
we reveal a new mode of intercellular communication by melanosomes, large EVs secreted …

Non-small-cell lung cancer (NSCLC) remains one of the leading causes of death worldwide.
While NSCLCs possess antigens that can potentially elicit T cell responses, defective tumor …

To uncover the intricate, chemotherapy-induced spatiotemporal remodeling of the tumor
microenvironment, we conducted integrative spatial and molecular characterization of 97 …

Glioblastoma (GBM) is the most common primary malignant brain tumor, with a median
overall survival of less than 2 years and a nearly 100% mortality rate under standard therapy …